1. diogenes0003@aol.com' Don Carroll
    January 14, 2012 @ 3:11 pm

    Excellent report on lithium – orotate. I have just recently
    began taking the “orotate”. I did feel a very slight feeling
    in my head for a short time during the day. But not now. I now don’t notice it at all.

    I’m quite happy so far and grateful for this research.

    Is Honesty and sincerity beginning to make a comeback!

  2. caitlindhage@mailc.net' mujeres solteras
    May 2, 2014 @ 4:10 pm

    Appreciate the recommendation. Will try it out.

  3. senn590@hotmail.com' Dave
    July 27, 2014 @ 1:35 pm

    Except the premise (“possibility”) that lithium orotate has higher bioavailability appears not to be true: Lithium orotate, carbonate and chloride: pharmacokinetics, polyuria in rats.Br J Pharmacol. 1976 Apr;56(4):399-402. No differences in the uptake, distribution and excretion of the lithium ion were observed between lithium orotate, lithium carbonate and lithium chloride after single intraperitoneal, subcutaneous or intragastric injections (0.5-1.0 mEq lithium/kg) or after administration of the lithium salts for 20 days in the food.

    There is evidence that low-dose lithium can be beneficial irrespective of which salt, but low-dose lithium orotate is not remotely equivalent to high-dose lithium carbonate. Sales of lithium carbonate and chloride are banned, that’s why orotate and aspartate are sold as supplements.

  4. Dr. Michelle Kmiec
    July 28, 2014 @ 10:35 am

    Hi Dave!Thanks for your comment! However, I always like to look who is doing the research. In this case, Pharmacol isn’t exactly an unbiased party. With that said, all research is very useful in finding the truth. Ed Sharpe wrote an article for Global Healing Center that is quite good. I like that the article is supported by research. You can find it HERE.

  5. maddypaints@gmail.com' Madeline Winter
    October 27, 2014 @ 8:16 pm

    Hi, I am a 65 year-old female who has been detoxing from antidepressants and benzodiazepines for over a year. My brain was fried after 20 years of pharmaceuticals. I recently developed symptoms of no-Pilate disorder with severe rapid cycling and suicidal thoughts. I found out about lithium orotate about 1 month ago. It has been helping. I have been trying to find the right dose. I will try the 30 mg per day. I was a mental health counselor, and I know that the meds caused my awful decline. I thank you for your work.

  6. kquilt@gmail.com' K
    February 8, 2015 @ 10:02 pm

    Hello Madeline, What is no-Pilate disorder?

  7. peace_moon_stars@yahoo.com' Marie
    February 17, 2015 @ 10:36 am

    I’m taking lithium carbonate 300 mg 2x a day and believe it is causing me weight gain. If I switch to lithium orotate, will it help me lose weight and how much should I take?

  8. peace_moon_stars@yahoo.com' Kelly
    May 4, 2015 @ 1:10 pm

    Im on 300 mg lithium carbonate also and wondering how much to take. I feel anxious if I wean down to 1x day but I need to stop the weight gain also. I’m thinking of getting the 120 mg lithium orotate. Thanks

  9. carolgotmail@gmail.com' Carol
    May 4, 2015 @ 6:46 pm

    Hi Michelle,
    I really like the layout of your article. I’ve been doing a lot of research on the internet and I’ve read just about every article you had referred to. Your article here is extremely comprehensive and easy to understand. You put all the information anyone would need on the subject of lithium orotate.

    My son was diagnosed bipolar 1 with psychosis and attempted suicide twice. Long story short, he’s doing great now and is only taking 900 mg/day of the lithium carbonate. I was researching lithium orotate for my personal severe insomnia and anxiety which has been ongoing for many years. When I found lithium orotate I decided to try it for myself. I’m a holistic nutritionist and wanted to take a natural supplement. I’ve tried everything else. I’ve only been taking it at bedtime for a few days and I need to give it time to see if the dosage needs to be tweaked.

    That said, I was trying yo tell my son,who is 27 yo, to ask his doc about switching. I’m sure he nervous to change anything because of what he’s been through.

    I’m really concerned about the future, almost guaranteed, kidney and thyroid damage. Any suggestions of how to help him understand? I’ve sent Jim articles and my husband doesn’t want me to push the issue.

    Thank you for a very interesting and clear read!

  10. Craigjcarlson@hotmail.com' Craig
    May 15, 2015 @ 8:47 pm

    Wonderful artical best one I’ve heard with lithium orotate(LO) I’ve been reading up on LO and how much LO per day would one have to take to reach a toxic level would you say? Thanks you

  11. bobfrostmail@aol.com' Jake
    August 12, 2015 @ 11:15 am

    I’ve been under a fair bit of stress lately (work related) and have been using alcohol in evenings to deal with it – a little bit too much of the stuff and a little bit too often. I haven’t regarded this as a problem but I’ve been monitoring the situation closely in the belief that booze can very quickly become a problem. I’ve been addressing the situation with supplements. I feel that 15 mg of elemental lithium orotate twice a day has been helpful. I also think I’ve benefited from a large intake of probiotics. My alcohol intake is down – I don’t feel the need for it – and I see these two products as essential in this regard. Also my mood seems better. (I also take a full range of other vitamins including injectable B12. And I take MSM. I balance Vitamin A with Vitamin D very carefully.)

  12. paolathome@hotmail.com' Ana Thome
    November 25, 2015 @ 10:02 am

    Hello, I read the 1979 abstract which says: “…The renal lithium clearance was significantly lower, the kidney weight and the lithium concentrations in serum, kidney and heart significantly higher after injection of lithium orotate than after injection of lithium carbonate…”
    It says that the concentration was higher with orotate than with carbonate
    It doesn´t make sense

  13. jy13@shaw.ca' Julianna
    November 28, 2015 @ 9:58 pm

    I’ve been on 600 mg lithium carbonate for too long and I took it down to 450 mg of lithium carbonate AND added 5 mg. of lithium orotate….I had massive headaches…for too long. I need some guidance as to how to make this transitions without withdrawals or having an episode.

  14. Miacinque@gmail.com' Mia
    December 27, 2015 @ 2:58 pm

    I very much need help transitioning from lithium carbonate to lithium orotate. I do not want to do it on my own! My physchiatrist never heard of it but has given me the green light to take any form of lithium as it has stopped my bipolar psychosis but irritates my bowel so. I’ve only been on it for one month.

    Please help. Need direction and advisement in order to make the switch and then spread the word if it helps me!

    Thank you!

  15. Miacinque@gmail.com' Mia
    December 27, 2015 @ 9:09 pm

    If I take 600mg lithium carbonate, how much lithium orotate would I take for the same affect?

  16. Dr. Michelle Kmiec
    December 28, 2015 @ 11:07 am

    200 mg would achieve the same effect

  17. careydubay@gmail.com' Carey
    January 27, 2016 @ 3:04 pm

    I tried to contact your drmichelle@… but can’t get through.
    I have Bi-polar disorder and have taken Lithium Carbonate for 20 years. I want to switch to Lithium Orotate. I presently take 900mg LC daily. How much LO would replace LC? If you can’t say for liability reasons, would you please explain how to figure it out? My body desperately needs to do this. This knowledge is a gift from God. Thank you so much!

  18. Sebaroussel@yahoo.fr' Sebastien
    May 5, 2016 @ 11:56 am

    I take 1200 mg lithium carbonate, how much lithium orotate i must take? Thank you for your help.

  19. ljmosher1@gmail.com' Linda Mosher
    May 18, 2016 @ 9:59 am

    Anyone who has Parkinson’s or other neurological diseases should read this article about a lithium study done. Link here:


    I have had some tremors and also suffer from PTSD but after taking lithium orotate
    the symptoms settled down so the article confirmed my suspicions that lithium was helping. I stopped the lithium of late and the symptoms have started to return. I was only taking 2.5-5 mgs of lithium orotate. This article says they used 1-2 mM but I don’t seem to find what kind they used or how much that really is. Any info you can offer would be helpful. It was recommended that it be used along with Parkinson’s drugs and/or valproic acid, so I need to do more research on where to get that as I am not on any meds for Parkinson’s.

  20. Lithium Alzheimer Treatment Options | Treatment for Alzheimer
    June 8, 2016 @ 12:02 pm

    […] Natural Treatment for Bipolar Disorder and Alzheimer’s … – Audio By: Dr Michelle Kmiec – Natural Treatment for Bipolar Disorder and Alzheimer’s Ignored! […]

  21. Softballfolks24@yahoo.com' Debbie
    June 29, 2016 @ 1:32 pm

    I was diagnosed with cyclothymic disorder 4 mos ago and prescribed lithium carbonate 300mg bid. I’m telling u it worked wonders and absolutely changed my life. I love it BUT one major problem…after about 2 months my hair started falling out!!! I bought selenium, biotin, primrose oil supplements but 2 months later since coming out. With the approval of my PCP I cut my lithium dose in half…1 month later it’s still falling out. My PCP doesn’t seem very concerned and believes at some point it will stop. He doesn’t want to change my med. I’m not willing to wait til I’m bald to make a move. I only have 1/3 of the hair I had before. I ordered lithium orotate on-line last nite and I’m hoping I can stay on lithium AND keep my hair!!! What dosage should I start with?

  22. andrewky_hillam@hotmail.com' Andrew
    June 30, 2016 @ 4:45 am

    Hi there, i have just started lithium carbonate, this is my first day on it, i really dont want to take it now due to all the side effects, and reading all these comments, The dr has started me on 250mg, how much lithium orotate would i need instead, thanks very much for your help.

  23. Olivia.heady@snhu.edu' Olivia
    July 4, 2016 @ 11:52 pm

    Hi Can you please let me know if Lithium orotate if taken as prescribed is effective for severe mania with delusions? I cannot find information whether or not it would be effective enough for my case of bipolar. I currently take ziprisadone, 80 mg daily, which is effective however I am not happy with the possibility of the severe side effects that can result from prolonged use of the medication.

  24. Dr. Michelle Kmiec
    July 11, 2016 @ 4:55 pm

    Hello, based on the formula in the article you would need less than 100 mg lithium orotate per day.

  25. Dr. Michelle Kmiec
    July 11, 2016 @ 4:57 pm

    Hello, I am not sure how lithium orotate compares to ziprisadone. Perhaps you can ask your doctor what amount of lithium carbonate they may suggest and then we could go from there. Perhaps lithium carbonate was not a good option for you since the dosage may have been too high, and thus a danger to your kidneys. If that is the case, then lithium orotate would be far healthier for you and likely very effective.

  26. Dr. Michelle Kmiec
    July 11, 2016 @ 4:58 pm

    Hello, to achieve the same effect you would start at 100 mg per day.

  27. Dr. Michelle Kmiec
    July 11, 2016 @ 4:59 pm

    Hello! To achieve the same effect based on the formula in the article you would need 400 mg lithium orotate per day.

  28. Dr. Michelle Kmiec
    July 11, 2016 @ 5:00 pm

    Hi! to achieve the same effect based on the formula in the article you would 300 mg lithium orotate per day. 🙂

  29. md.younus.87@gmail.com' Jonah
    July 13, 2016 @ 12:59 pm


    I have been taking Lithium Carbonate 300 mg (3 tablets for total of 900 mg) for 2 years now. Helped keep my bipolar in check. Had good results until one fine day my tinnitus got worse. I stopped taking it but 2 months and tinnitus symptoms still didnt go away. Visited ENT, he said if tinnitus is due to Lithium – it should have stopped after discontinuing the medicine, he advice me to start again since stopping didnt really help. My hearing tests were normal – no hearing loss. Consulted my psychiatrist again and he also recommended restarting Lithium, I did and after a couple of days tinnitus got worse!!! I stopped again this time deciding that I will not start again regardless what the doctors say!!!

    Now i came across this Lithium Orotate and considering to take it to manage my Bipolar condition. Any recommendations would be welcome, what dosage should I start with?

    FYI – my lab result for my for Lithium, Serum is <0.1. Normal range should be 0.6-1.4

  30. themrne4life@ymail.com' LJ
    July 13, 2016 @ 11:24 pm

    When you tell someone too take 300mg a day do you just mean the total mg of the Orotate pill taken or ensure that they are taking 300mg of Lithium?

  31. Dr. Michelle Kmiec
    July 14, 2016 @ 6:28 am

    Hello, if you read the article especially the area where it states the formula of equivalence between lithium carbonate and orotate, the key thing is to also look at the elemental. 300 mg of lithium carbonate is not the same as lithium oroate. The same achieve effect however occurs with 100 mg of lithium oroate. When I suggest to someone the amount to take, I am referring to the formula that is stated within the article.

  32. angelab45@optus.com.au' Mary
    July 20, 2016 @ 6:19 pm

    I just learned that Lithium Orotate is banned in Australia. I have ordered 5 mg tablets from USA a few times without any trouble so it must have been a fluke that they got through customs. I don’t know what to do now as I want to keep taking it. I don’t have any serious health problems I just like to take it as a preventive measure against alzhiemers.

  33. Lanopistar@aol.com.com' Shirley R Harper
    August 18, 2016 @ 2:18 pm

    If you take lo is there a problem if you stop taking it? I have no problems bipolar anything I’m just an older woman and I have a lot of serious things that happened to me death of my husband death of my daughter and I don’t want to start something that would cause me to continue to have to take it thank you for any answer on this

  34. Coulchy@live.com.au' Michelle coulch
    August 25, 2016 @ 3:55 am

    I just bought lithium orotate in the us as i couldn’t get it in Australia. Might have to stock pile it if its banned. Going to try it tonight.

  35. bobbyreidel@yahoo.com' bob reidel
    August 29, 2016 @ 1:37 pm

    I have been using orotate form for 2 years now. what a great pleasure to get out of the crazy world of psychiatry. most shrinks are nuts themselves! our food today is a major cause of bi polarism. the soils are deficient in all forms of minerals. i love the results of taking a cheap mineral suppliment as necessary. IT WORKS EXACTLY AS DESCRIBED. i also use prozac for depression. i am a type two bipolar. mostly depression with bouts of mania. the AMA is a corrupt organization who wants ever one sick on something to continue raking in billions. from drug companies. my experience with this opened my eyes to alternative medicine.since then i have been doing a great amount of research in alternative medicine. i am astonished to see numerous cures for cancer and many other sicknesses. no wonder DR.ROYAL RIFE was destroyed by the AMA in 1930. he found cures for jbobust about any illness and demonstrated those cures.

  36. vincenze333@gmail.com' vince k
    August 29, 2016 @ 5:42 pm

    great article and speech. Can i suggest a product called neurofuzion. its lithium orotate, zinc, and some herbs.while the advanced research brand has a lot of unhealthy binders. http://www.globalhealingcenter.com/neurofuzion.html

  37. akefmasood@gmail.com' Akef Masood
    September 17, 2016 @ 7:42 am

    Dr. Michelle Kmiec
    Very rerelived to read your article. I m taking lithium carbonate (Licab XL400 mg) 2 times a day. Plz tell me what would be the quantity equivalent of lithium orotate.

  38. lilly@wolke7.net' Isabelle
    September 23, 2016 @ 11:44 am

    I’m from Germany, ordered Lithium orotate in the UK. I’ve just started – yesterday 5mg, today 10mg essential Lithium.
    I didn’t feel a change whatsoever. Maybe my eyes were a bid dryer when I woke up.

    You recommend dosages – but I don’t understand if it’s the essential Lithium.

    I believe more in classic medicine and I’m not holistic at all. But I think one should stay open and try new things. But if I have to take more that 2 pills (10mg essential Lithium) a day it’d become too expensive for me.

    And when the Brexit is done I won’t be able to order it anymore.

    Well, but I’m curious if I’m going to feel a difference – there are still 58 pills to take.
    I will publish it online as there isn’t much information about the orotate in Germany.

  39. OHH@rmaarons.mailworks.org' roger aarons
    October 20, 2016 @ 4:04 pm

    I just started taking lithium orotate again. I had been taking it for a while a few years ago, but don’t remember much about my experience with it.

    One thing I am concerned about is the fact that lithium, 5-HTP, and SAM-e all boost serotonin levels and, while such a boost is very helpful up to a point, too much serotonin can be harmful and even deadly. I’ve temporarily cut way back on the 5-HTP, since its only function seems to be to increase serotonin, while lithium and SAM-e seem to have other useful functions as well. But I would like to have a better way of deciding on my intake of these supplements. In particular, I’m wondering what might be early warning signs of too much serotonin in the brain, as well as what might be clear indications of too little.

    P.S. I’m 75 years old. I have, at times, taken Paroxetine (Paxil) and, years ago, Zoloft, but I see no reason to take them as opposed to other, more natural, ways to boost serotonin levels — provided that I can regulate my intake intelligently.

  40. Ssr_clr@yahoo.com' Christina Jones
    March 16, 2017 @ 4:27 pm

    Can you take lithium ortate while pregnant?

  41. joshua.castillo12@gmail.com' Joshua
    June 9, 2017 @ 2:02 am

    I have a family member that does not react well to Lithium orotate (she gets headaches and migranes). I understand from my research that there are other orotates that are important for brain funciton as well. Does anyone have info on what those would be?

  42. jeansunnyi@gmail.com' Jean Yi
    August 8, 2017 @ 9:28 pm

    My daughter takes 900 mg of lIthium carbonate ER and takes 75 mcg of synthroid. She needs thyroid medication because of the lithium carbonate….diagnosed as Bipolar one.

    How much of the lithium orate would she need? Would she just stop taking lithium carbonate and start taking orate all at once? Is this safe? Would she still have to take thyroid medication?


  43. Linda.m.frazier@gmail.com' Linda
    March 26, 2018 @ 10:50 pm

    I would really like to read some answers to these questions also. I haven’t heard any updates on anyone who said they just started and it’s been over a year or longer.

  44. Online Holistic Health
    March 27, 2018 @ 10:21 am

    Hello Linda! There are links in the article that redirects you to the people who were making the film and to those who have reversed the illness. But let me just post it here. I think you will find this site (healing als) very interesting!

    Wishing you all the best1

  45. gmginsberg@gmail.com' Gary Ginsberg
    April 7, 2019 @ 3:38 am

    We are about to move my son gradually onto Lithium Orotate from Lithium Carbonate, but we have a query regarding possible reductions of toxicity to the kidneys………….perhaps you can help us.

    It seems there are two theories.

    A) That since 120mg of Li Orotate and 300mg of li Carbonate deliver to the brain similar amounts of Lithium, the brain then excretes these similar amounts from the body via the kidneys. Hence while Carbonate might be easier on the gastro intestinal system on the way into the body, there is absolutely no reduction of toxicity to the kidneys in transferring from Carbonate to Orotate.

    B) As carbonate has a far lower absorption rate, some (or all) of the excess goes out through the gut (by-passing the kidneys) but in addition some (or all) gets absorbed into the bloodstream but is mainly not absorbed into the brain and this passes out through the kidneys —- Hence moving over to orotate will mean a reduction of kidney toxicity as the gut-bloodstream-kidney route is reduced in magnitude.

    Please could you help us in understanding what theory is correct? or put it simply
    will transferring to Orotate reduce Kidney toxicity


  46. bdrs20@comcast.net' Becky Subrahmanyam
    October 15, 2019 @ 5:43 pm

    Can Lithium Orotate be taken WITH Abilify?

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